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NASAL POLYPS: EPIDEMIOLOGY,
PATHOGENESIS AND TREATMENT

Edited by: Guy A. Settipane, M.D., Valerie J. Lund, M.S., FRCS, Joel Bernstein, M.D., Ph.D., and Mirko Tos, M.D., Ph.D.

Twenty nine experts in nasal polyps are authors in this 21 chapter book. All chapters have abstracts for those who wish to skim the book. Sixteen authors are Otolaryngology surgeons, and 13 are experts in related medical fields that deal with various aspects of nasal polyps. The aim of this book is to help physicians better understand nasal polyps and help reduce the high lecurrence rate.

TABLE OF CONTENTS

Chapter I INTRODUCTION
Guy A. Settipane, M.D., Valerie J. Lund, M.S., Joel M. Bernstein, M.D., Ph.D., Mirko Tos, M.D., Ph.D.

Chapter II HISTORICAL BACKGROUND
David J. Brain, M.D.

Chapter III EPIDEMIOLOGY
Guy A. Settipane, M.D.

Chapter IV ANATOMY OF THE NOSE AND SINUSES
Ian S. Mackay, M.D.

Chapter V HISTOPATHOLOGY
Henrik B. Hellquist, M.D., Ph.D.

Chapter VI CHEMICAL MEDIATORS IN POLYPS
Hal M. Hoffman, M.D. and Stephen I. Wasserman, M.D.

Chapter VII EOSINOPHILS IN NASAL POLYPS
Manel Jordana, M.D., Ph.D., and Jerry Dolovich, M.D.

Chapter VIII

THE PATHOGENESIS OF NASAL POLYPS
Adrian Drake-Lee, Ph.D.

Chapter IX EARLY STAGES OF POLYP FORMATION
Mirko Tos, M.D., Ph.D.

Chapter X BASIC SINUS IMAGING AND RADIOLOGICAL ASPECTS OF NASAL POLYPOSIS
Patrick J. Oliverio, M.D., Mark L. Benson, M.D., and S. James Zinreich, M.D.

Chapter XI THE IMMUNO HISTOPATHOLOGY AND PATHOPHYSIOLOGY OF NASAL POLYPOSIS (THE DIFFERENTIAL DIAGNOSIS OF NASAL POLYPOSIS)
Joel M. Bernstein, M.D., Ph.D.

Chapter XII THE CLINICAL RELATIONSHIP OF NASAL POLYPS TO ASTHMA
Knud Larsen, M.D.

Chapter XIII NASAL POLYPS AND IMMUNOGLOBULIN E (IGE)
Guy A. Settipane, M.D.

Chapter XIV NASAL POLYPS AND ASPIRIN INTOLERANCE
Guy A. Settipane, M.D., and Russell A. Settipane, M.D.

Chapter XV NASAL POLYPS: RELATIONSHIP TO INFECTION AND INFLAMMATION
Pontus L.E. Stiema, M.D., Ph.D.

Chapter XVI ALLERGIC FUNGAL SINUSITIS/POLYPOSIS
John P. Bent III, M.D. and Frederick A. Kuhn, M.D.

Chapter XVII NASAL POLYPS IN CYSTIC FIBROSIS
Peter M. G. Deane, M.D. and Robert H. Schwartz, M.D.

TREATMENT

Chapter XVIII MEDICAL MANAGEMENT
Niels Mygind, M.D., and Torben Lildholdt, M.D., Ph.D.

Chapter XIX SURGICAL TREATMENT - NASAL POLYPS
Valerie J. Lund, M.S., FRCS

Chapter XX RHINOSCOPIC SURGERY
Heinz Stammberger, M.D.

Chapter XXI OUTCOME AND COMPLICATIONS OF SURGICAL TREATMENT
Maurice Roth, M.D., David W. Kennedy, M.D.

"(This book on nasal polyps) shows how multiple disciplines including general internal medicine, otolaryngology, pediatrics, infectious diseases, pulmonology, pathology, basic sciences, allergy and clinical immunology are all contributing a certain degree of knowledge toward improving our understanding of nasal polyp formation. It seems clear that this type of multidisciplinary approach will go a long way toward solving the many remaining problems in etiology pathogenesis and management of these intriguing conditions".

·  John E. Salvaggio Henderson Professor of Medicine and Vice Chancellor, Tulane University Medical Center, New Orleans, LA

"Nasal polyposis is not a rare condition. Therefore this book, Nasal Polyps, Epidemiology, Pathogenesis and Treatment which is the first book devoted entirely to the subject is long overdue. The Editors have enlisted a stellar group of contributors whose knowledge and expertise are recognized internationally in laboratory research, clinical investigation or clinical practice. With their critical insights the authors are able to provide in depth presentations of the various facets of this illness. In a logical and systematic fashion, the authors cover the Historical Background, Epidemiology, Anatomy, Histopathology, Pathogenesis, Immunology, Pathophysiology, Clinical Relationships, Diagnosis and both Medical and Surgical Therapy.

Since the etiology of nasal polyps has not been defined, this condition presents a challenge to many clinicians. In addition, nasal polyps have been associated with conditions such as cystic fibrosis, aspirin sensitivity and allergic fungal sinusitis which are quite different in their pathogenesis and manifestations. The relationships of other mechanisms are presented in a clear understandable manner. The same can be said for the chapter that discusses the management of polyps, both medical and surgical. Therefore this book will be of interest to not only otolaryngologists but also physicians interested in infectious disease, pediatrics, internal medicine, allergy and clinical immunology."

·  Philip Fireman, M.D., Professor of Pediatrics and Medicine, University Of Pittsburgh, School of Medicine

NASAL POLYPS
Edited by: Guy A. Settipane, M.D., Valerie J. Lund, M.S., FRCS, Joel Bernstein, M.D., Ph.D., and Mirko Tos, M.D., Ph.D.

202 pages, Hardcover
26 Color Figures
1997

ORDERING INFORMATION:
$98.00 (outside U.S.A., $128.00)
ISBN 0-936587-09-1

Textbook order forms.



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